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Methods in Enzymology, Volume 449

Megerditch Kiledjian, Lynne E. Maquat · ISBN 9780123743787
Methods in Enzymology, Volume 449 | Zookal Textbooks | Zookal Textbooks
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Publisher Academic Press
Author(s) Megerditch Kiledjian / Lynne E. Maquat
Edition 1
Published 15th December 2008
Related course codes
Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements, responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. The control of biological processes, such as cellular growth and differentiation, is dependent on how the genetic material within a cell is expressed. The cellular physiology of mRNA-including mRNA processing, transport, localization, and turnover-is central to the process of gene expression. Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway. Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover which are central to the process of gene expression.Offers step-by-step lab instructions including necessary equipment and reagents
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